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Polycystic Ovaries and Hyperandrogenism in Women Taking Valproate for Epilepsy NEJM 329:1383-1388, Isojarvi,J.I.T.,et al, 1993 See this aricle in Pubmed Article Abstract Menstrual disturbances were present in 13 of the women receiving valproate alone(45 percent),3 of the women receiving valproate in combination with carbamazepine(25 percent),23 of the women receiving carbamazepine(19 percent),and 8 of those receiving other medications(13 percent).Forty- three percent of the women receiving valproate had polycystic ovaries,and 17 percent had elevated serum testosterone concentrations without polycystic ovaries;50 percent of the women receiving valproate and carbamazepine had polycystic ovaries,and 38 percent had elevated serum testosterone concentrations without polycystic ovaries.Eighty percent of the women treated with valproate before the age of 20 years had polycystic ovaries or hyperandrogenism.Menstrual disturbances,polycystic ovaries,and hyperandrogenism are often encountered in women taking valproate for epilepsy.

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(click to filter results - removes previous filter) adverse drug reaction anticonvulsants,untoward effects of menses,irregular polycystic ovarian syndrome seizure sodium valproate testosterone testosterone,serum testosterone,serum,elevated

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